LONGEVITY BIOMARKERS
What we test
100+ labs that provide the most complete
picture of your current and future health.
Biomarkers Tested
With Ultimate Longevity screening, you gain access to 100+ lab tests annually, covering a wide range of biomarkers. Explore advanced and specialty biomarkers tailored to meet your health needs.
Join us in taking proactive steps towards building your comprehensive health baseline, and earlier interventions to live healthy, longer.
- The biomarker and ratio descriptions herein are for general information purposes only. They are not intended to diagnose, assign risk, or recommend treatment. Please discuss your results with a qualified healthcare practitioner.
Heart Health & Longevity
Apolipoprotein B
Protein found on many “bad” cholesterol particles; higher levels reflect a greater number of these particles in the blood.
Total Cholesterol
Total amount of cholesterol circulating in the blood, including HDL, LDL, and other cholesterol fractions, used as an overall snapshot of blood cholesterol levels to help assess long‑term cardiovascular risk.
Non-HDL Cholesterol
Total cholesterol minus HDL; often used as a simple way to estimate cholesterol particles that may be more strongly linked with heart and vascular risk.
HDL Cholesterol
“Good” cholesterol that helps carry cholesterol away from arteries and back to the liver for processing and removal.
Triglycerides
The main form of fat circulating in the blood, influenced by diet, weight, and metabolic health, and used as a general indicator of how the body is handling fats and energy over time.
LDL-Cholesterol
“Bad” cholesterol particles that can contribute to plaque build-up in blood vessel walls over time.
Castelli Risk Index I (Total Cholesterol/HDL)
Research-based ratio comparing total cholesterol to HDL cholesterol, explored as one way of estimating long-term cardiovascular risk.
Castelli Risk Index II (LDL/HDL)
Research-based ratio comparing LDL cholesterol to HDL cholesterol, used in studies as another way of describing cardiovascular risk.
LDL Cholesterol/Total Cholesterol (Mass Ratio)
Exploratory research ratio showing what proportion of total cholesterol is made up of LDL cholesterol, used as a high-level way to describe overall cholesterol balance.
Non-HDL/Total Cholesterol Ratio
Exploratory research ratio showing what proportion of total cholesterol is made up of non‑HDL (“non‑good”) cholesterol, used as a high‑level way to describe overall cholesterol balance.
Triglyceride HDL Molar Ratio
Research ratio comparing triglycerides to HDL cholesterol, explored in studies of metabolic and cardiovascular risk.
Atherogenic Index of Plasma (AIP)
Log-based ratio of triglycerides to HDL cholesterol investigated in research as a marker of blood lipid patterns linked with cardiovascular risk.
Atherogenic Coefficient
Research ratio that compares non-HDL (“atherogenic”) cholesterol to HDL cholesterol to summarize overall lipid balance.
Triglyceride/Apolipoprotein B ratio TG/ApoB
Exploratory research ratio looking at how triglyceride levels relate to the number of ApoB‑containing particles, used as a high‑level way to describe overall blood fat patterns.
LDL-C to Apolipoprotein B Ratio (LDL-C/ApoB)
Research ratio comparing LDL cholesterol to ApoB, used to describe whether LDL particles tend to be smaller and denser or larger and more buoyant, as a high‑level summary of LDL particle pattern.
Uric Acid-to-HDL Cholesterol Ratio (UHR)
Research ratio comparing uric acid to HDL cholesterol, explored in studies of metabolic and cardiovascular risk.
Neutrophil-to-HDL Cholesterol Ratio (NHR)
Emerging research ratio combining a type of white blood cell (neutrophils) with HDL cholesterol to explore links between inflammation and cardiovascular risk.
Testosterone/ApoB
Exploratory research ratio comparing testosterone levels with ApoB, used in studies of hormone balance and lipid-related risk.
Metabolic Health Biomarkers
Glucose
Amount of sugar circulating in the blood at the time of the test, reflecting short-term blood sugar control.
Hemoglobin AIC
Measure of how much sugar has been attached to red blood cells over the past few months, reflecting longer-term blood sugar patterns.
Uric Acid
Waste product from the breakdown of certain foods and body tissues; higher levels can be linked with gout and metabolic health.
(Triglyceride - Glucose Index) - TyG Index
Research index combining fasting triglycerides and glucose to describe patterns linked with insulin resistance and cardiometabolic risk.
TyG-BMI Index
Research index that combines the TyG index with body mass index (BMI) to explore how weight and metabolism interact in diabetes and cardiometabolic risk studies.
Corrected Calcium (Albumin-adjusted)
Calculated estimate of blood calcium that adjusts for albumin levels so calcium status can be interpreted more consistently.
Energy Biomarkers
Iron (Total)
Amount of circulating iron in the blood at the time of the test, helping to put iron availability and related symptoms into context when viewed with other iron and blood markers.
Total Iron Binding Capacity
Estimate of how much iron the blood can carry, based largely on transferrin, the main iron-transport protein.
Iron Saturation
Percentage of available iron-binding sites on transferrin that are currently filled with iron.
Ferritin
Protein that stores iron in the body; also influenced by inflammation.
Cortisol
Hormone made by the adrenal glands that helps the body respond to stress. regulate blood sugar, and manage inflammation.
RDW/Ferritin Ratio
Exploratory research ratio combining a red blood cell variability marker (RDW) with an iron-storage protein (ferritin), used as a high-level way to describe how red blood cell patterns and stored iron may relate to each other rather than as a stand-alone clinical marker.
Cortisol-to-DHEA-S Ratio
Research ratio comparing cortisol and DHEA-S, used to explore adrenal balance and stress-related patterns.
Thyroid Health Biomarkers
Thyroxine (T4) Total
Total amount of thyroxine hormone made by the thyroid gland, including both bound and free forms, providing an overall snapshot of thyroid hormone output
that can help give context for how the thyroid is functioning over time.
alongside other thyroid tests and clinical review.
Free Thyroxine Index
Calculated value that combines total T4 and thyroid hormone binding to estimate the amount of active, unbound thyroid hormone.
Thyroid-Stimulating Hormone (TSH)
Hormone released by the brain’s pituitary gland that signals the thyroid to make more or less thyroid hormone.
Triiodothyronine (T3)
Active thyroid hormone that helps regulate energy use, metabolism, and many body functions.
Sex Hormones Biomarkers
Testosterone, Total
Total amount of testosterone in the blood, including both bound and unbound forms, providing an overall snapshot of hormone levels that can help give context to symptoms and wellbeing.
Sex Hormone Binding Globulin (SHBG)
Protein that binds sex hormones like testosterone and estradiol in the blood, controlling how much is freely available to tissues.
DHEA-Sulfate (DHEA-S)
Hormone produced mainly by the adrenal glands that acts as a building block for other sex hormones.
Testosterone, Free
Portion of testosterone that is not tightly bound to proteins and is more readily available for the body to use.
Estradiol
Form of estrogen that plays a key role in menstrual cycles, bone health, and many other body systems in all genders.
Testosterone-to-Estradiol Ratio (T/E2)
Research ratio comparing testosterone and estradiol, explored in studies of hormone balance and symptoms.
Free Androgen Index (FAI)
Calculated estimate of how much biologically active (free) androgen is available relative to binding proteins, offering a high‑level view of overall androgen availability that can help put symptoms and hormone patterns in context.
Liver Health Biomarkers
Albumin
Main protein made by the liver that helps maintain fluid balance and carries hormones, vitamins, and medicines in the blood.
Globulin A/G Ratio
Ratio comparing albumin to globulins, giving an overview of the major protein groups in the blood and helping to frame patterns related to liver function, nutrition, and immune activity when interpreted with other results.
Alkaline Phosphatase (ALP)
Enzyme found in liver, bile ducts, and bone; used to explore patterns related to liver or bone conditions.
Alanine Aminotransferase (ALT)
Enzyme mainly found in the liver; higher levels can indicate liver cell irritation or damage.
Aspartate Aminotransferase (AST)
Enzyme found in the liver, heart, and muscles. AST is usually interpreted together with ALT and other markers to help describe patterns of liver and muscle stress over time.
Globulin, Total
Grouped measure of blood proteins other than albumin, including many antibodies and transport proteins. This helps give a broad view of immune and protein status when considered alongside other tests.
Bilirubin, Total
Yellow pigment produced when red blood cells are broken down; higher levels can change skin or eye colour and may signal liver or bile duct issues.
Bilirubin, Indirect
Form of bilirubin before it is processed by the liver. It helps give context on how red blood cells are being broken down and how bilirubin is being handled in the body.
y - Glutamyl Transferase (GGT)
Enzyme found mainly in the liver and bile ducts, often used to explore patterns of liver or bile duct stress and alcohol exposure.
Bilirubin-to-Albumin Ratio
Research ratio comparing bilirubin to albumin, explored in studies of severe illness and liver-related risk.
GGT-to-HDL Cholesterol Ratio
Emerging research ratio relating a liver enzyme (GGT) to HDL cholesterol, studied in metabolic and liver health research.
Bilirubin, Direct
Form of bilirubin after it has been processed by the liver and made ready for removal from the body. It helps describe how well bile flow and bilirubin clearance are working when viewed with other liver markers.
De Ritis (AST/ALT) Ratio
Ratio comparing AST to ALT that can help describe different patterns of liver enzyme changes.
Indirect-to-Direct Bilirubin Ratio
Exploratory ratio comparing unconjugated and conjugated bilirubin to describe how bilirubin is being processed.
GGT/ALT
Research ratio comparing two liver-related enzymes, used mainly in studies to explore liver and metabolic patterns.
Kidney Health Biomarkers
Blood Urea Nitrogen (BUN)
Measure of urea nitrogen, a waste product filtered by the kidneys, giving information about kidney function and protein breakdown.
BUN/Creatinine Ratio
Ratio of two kidney-related markers (BUN and creatinine) often used to help interpret hydration status and kidney function.
Calcium
Mineral important for bones, muscles, nerves, and blood clotting, tightly regulated in the blood.
Carbon Dioxide, Total
Measure related to bicarbonate and carbon dioxide in the blood, giving information about acid–base balance and breathing.
Chloride
Electrolyte that helps maintain fluid balance and acid–base balance in the body.
Creatinine
Waste product from muscle metabolism that is filtered by the kidneys; commonly used to estimate kidney function.
Estimated Glomerular Filtration Rate (eGFR)
Calculated estimate of how well the kidneys are filtering blood each minute.
Potassium
Electrolyte that supports heart rhythm, nerve signals, and muscle function.
Sodium
Electrolyte that helps control fluid balance, blood pressure, and nerve and muscle function.
Urea-to-Creatinine Ratio
Ratio comparing total urea to creatinine, similar in use to the BUN/creatinine ratio in interpreting kidney-related patterns.
Cockcroft-Gault Creatinine Clearance
Calculated estimate of how much blood the kidneys clear of creatinine each minute, often used in research and dosing decisions.
Thyroid Health Biomarkers
Thyroxine (T4) Total
Total amount of thyroxine hormone made by the thyroid gland, including both bound and free forms, providing an overall snapshot of thyroid hormone output
that can help give context for how the thyroid is functioning over time.
alongside other thyroid tests and clinical review.
Free Thyroxine Index
Calculated value that combines total T4 and thyroid hormone binding to estimate the amount of active, unbound thyroid hormone.
Thyroid-Stimulating Hormone (TSH)
Hormone released by the brain’s pituitary gland that signals the thyroid to make more or less thyroid hormone.
Triiodothyronine (T3)
Active thyroid hormone that helps regulate energy use, metabolism, and many body functions.
Nutrients Biomarkers
Red Blood Cells
Cells that carry oxygen from the lungs to the rest of the body and return carbon dioxide to the lungs to be exhaled.
Hematocrit
Oxygen-carrying protein inside red blood cells that gives blood its red color.
Hematocrit
Percentage of blood volume made up of red blood cells.
Mean Cell Volume (MCV)
Average size of red blood cells, used to help understand different types of anaemia.
Mean Cell Hemoglobin (MCH)
Average amount of hemoglobin in each red blood cell.
Mean Corpuscular Hemoglobin Concentration
Average concentration of hemoglobin inside red blood cells.
Red Cell Dist Width (RDW)
Measure of how much red blood cell sizes vary from one another. It is often used alongside other red blood cell markers to help frame different patterns of anaemia and nutrient status.
Platelet Count
Number of platelets, the blood cells that help with clotting and wound healing.
Mean Platelet Volume (MPV)
Average size of platelets, used together with platelet count to understand platelet activity.
Vitamin D
Vitamin involved in bone health, immune function, and many other processes.
RDW/MCV Ratio
Research ratio comparing variation in red blood cell size with their average size, mainly explored in studies of different anaemia patterns.
Immune System Biomarkers
White Blood Cells
Total number of white blood cells, which are part of the immune system and help the body respond to infection and inflammation.
Neutrophils
Type of white blood cell that helps the body respond quickly to infections and acute inflammation.
Neutrophils (Absolute)
Number of neutrophils in a set volume of blood, giving a more precise view of this immune cell type and helping to put patterns of infection or inflammation into context.
Lymphocytes
Type of white blood cell involved in targeted immune responses, including B cells. T cells, and natural killer cells.
Lymphs (Absolute)
Number of lymphocytes in a set volume of blood, used to understand overall lymphocyte status.
Monocytes
Type of white blood cell that can move into tissues and mature into cells that help clean up damage and support immune responses.
Monocytes (Absolute)
Number of monocytes in a set volume of blood, giving more detail about this part of the immune system.
Eosinophils
Type of white blood cell that can increase with allergies, asthma, and some infections.
Eosinophils (Absolute)
Number of eosinophils in a set volume of blood, used to further explore allergic or inflammatory patterns.
Basophils
Rare type of white blood cell involved in allergic and inflammatory responses.
Basophils (Absolute)
Number of basophils in a set volume of blood, providing a more detailed view of this rare immune cell type that can help put allergy- or inflammation-related patterns into context.
Lymphocyte-to-Monocyte Ratio (LMR)
Research ratio comparing lymphocytes and monocytes, used to explore immune balance in different conditions.
Platelet-to-WBC Ratio (PWR)
Research ratio comparing platelet count to total white blood cells, used mainly in studies of blood and immune health.
Neutrophil-to-Lymphocyte Ratio (NLR)
Research ratio comparing neutrophils to lymphocytes, often used to describe patterns of systemic inflammation in studies.
Neutrophil-to-Lymphocyte-Platelet Ratio (NLPR)
Emerging research ratio that combines neutrophils, lymphocytes, and platelets to explore complex inflammatory patterns.
Monocyte-to-Lymphocyte Ratio (MLR)
Research ratio comparing monocytes to lymphocytes, investigated in studies of chronic inflammation and immune activity.
Inflammation Biomarkers
C-Reactive Protein (CRP)
Protein made by the liver that rises when there is inflammation somewhere in the body.
Ferritin-to-Albumin Ratio (FAR)
Research ratio comparing ferritin, a marker of iron stores and inflammation, with albumin, a blood protein linked with nutrition and liver function.
CRP-to-Albumin Ratio (CAR)
Research ratio that relates inflammation (CRP) to albumin levels and has been studied in severe illness.
hs-CRP
High-sensitivity version of the CRP test that can detect lower levels of inflammation, often used in cardiovascular research.
Systemic Immune-Inflammation Index (SII)
Research index combining platelets, neutrophils, and lymphocytes to summarize immune and inflammatory activity.
Monocyte-to-HDL Ratio (MHR)
Research ratio comparing monocytes to HDL cholesterol, explored as a marker linking inflammation and cardiovascular risk.
Platelet-to-Lymphocyte Ratio
Research ratio comparing platelets to lymphocytes, used in studies of systemic inflammation and outcomes.
Systemic Inflammation Response Index (SIRI)
Research index combining neutrophils, monocytes, and lymphocytes to explore inflammatory response patterns.
Systemic CRP-to-Lymphocyte RatioResponse Index (SIRI)
Research ratio relating CRP to lymphocytes, studied as a marker of inflammation in certain conditions.
Ferritin/CRP Ratio
Research ratio comparing ferritin and CRP to help distinguish different patterns of iron status and inflammation in studies.
CRP/DHEA-S Ratio
Exploratory research ratio relating an inflammation marker (CRP) to an adrenal hormone (DHEA-S), used as a high-level way to describe how inflammation and adrenal hormone patterns may relate to each other.
Testosterone/CRP
Exploratory research ratio comparing testosterone levels with CRP as one way of looking at hormone-inflammation relationships.
Thyroid Health Biomarkers
Thyroxine (T4) Total
Total amount of thyroxine hormone made by the thyroid gland, including both bound and free forms, providing an overall snapshot of thyroid hormone output
that can help give context for how the thyroid is functioning over time.
alongside other thyroid tests and clinical review.
Free Thyroxine Index
Calculated value that combines total T4 and thyroid hormone binding to estimate the amount of active, unbound thyroid hormone.
Thyroid-Stimulating Hormone (TSH)
Hormone released by the brain’s pituitary gland that signals the thyroid to make more or less thyroid hormone.
Triiodothyronine (T3)
Active thyroid hormone that helps regulate energy use, metabolism, and many body functions.
